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Showing 1 to 12 of 49 entries
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Gompertz - A program for evaluation and comparison of survival curves.

Journal of the American Aging Association

Klemera P, Doubal S.
PMID: 23604852
J Am Aging Assoc. 2000 Jul;23(3):129-32. doi: 10.1007/s11357-000-0014-9.

Principles, properties and use of a program for evaluation of survival curves are described. Parameters of Gompertzian mortality curves are computed from survival data of two populations by help of nonlinear regression. The differences in parameters of both curves...

Insulin receptors in mouse brain: Reversibility of age-related impairments by a thymic extract.

Journal of the American Aging Association

Zaia A, Piantanelli L.
PMID: 23604853
J Am Aging Assoc. 2000 Jul;23(3):133-9. doi: 10.1007/s11357-000-0015-8.

Recently, we have shown that insulin receptors (InsRs) in the brain undergo impairments with aging. Interestingly, age-related alterations of brain InsRs, are not irreparable as thymus grafts are able to recover them. With the present study we verified the...

TCR Vβ repertoire in an Italian longeval population including centenarians.

Journal of the American Aging Association

Pennesi G, Morellini M, Lulli P, Cappellacci S, Brioli G, Franceschi C, Trabace S.
PMID: 23604877
J Am Aging Assoc. 2001 Apr;24(2):63-70. doi: 10.1007/s11357-001-0009-1.

During the last years, the hypothesis that aging and diseases are two distinct phenomena, and that successful aging is possible for most humans, has been put forward. We studied the TCR Vβ repertoire of T lymphocytes of healthy longevals...

Survival and cell mediated immunity after burn injury in aged mice.

Journal of the American Aging Association

Kovacs EJ, Grabowski KA, Duffner LA, Plackett TP, Gregory MS.
PMID: 23604885
J Am Aging Assoc. 2002 Jan;25(1):3-9. doi: 10.1007/s11357-002-0001-4.

The elderly are less able to survive burn injury than young healthy individuals. Regardless of age, burn victims often succumb to secondary infections rather than the primary injury. Since immune responses diminish with age, it is likely that aged...

Endocrine and metabolic changes in human aging.

Journal of the American Aging Association

Banks WA, Morley JE.
PMID: 23604844
J Am Aging Assoc. 2000 Apr;23(2):103-15. doi: 10.1007/s11357-000-0011-z.

Numerous alterations in hormonal secretion occur with aging. In general, these tend towards a disintegration of the normal cyclic secretory patterns resulting in lower total circulating levels. In addition, declines in receptors and postreceptor function further decreases the ability...

Role of xanthine dehydrogenase and aging on the innate immune response of Drosophila.

Journal of the American Aging Association

Kim YS, Nam HJ, Chung HY, Kim ND, Ryu JH, Lee WJ, Arking R, Yoo MA.
PMID: 23604884
J Am Aging Assoc. 2001 Oct;24(4):187-93. doi: 10.1007/s11357-001-0020-6.

It has been proposed that uric acid is an important scavenger of deleterious oxygen species and peroxynitrite in biological systems. The cellular sources responsible for the generation of damage-causing reactive oxygen species (ROS) are widespread. Xanthine dehydrogenase (XDH) /...

Lasofoxifene (CP-336,156), a novel selective estrogen receptor modulator, in preclinical studies.

Journal of the American Aging Association

Ke HZ, Brown TA, Thompson DD.
PMID: 23604900
J Am Aging Assoc. 2002 Apr;25(2):87-99. doi: 10.1007/s11357-002-0007-y.

Estrogen replacement therapy is reported to reduce the incidence of vertebral fractures in postmenopausal women, however, its compliance is limited because of side effects and safety concerns. Estrogen's side effects on breast and uterine tissues leading to the potential...

AgingDB: A database for oxidative stress and calorie restriction in the study of aging.

Journal of the American Aging Association

Park DU, Kim CH, Hong SE, Yu BP, Chung HY.
PMID: 23604914
J Am Aging Assoc. 2003 Jan;26(1):11-7. doi: 10.1007/s11357-003-0002-y.

Aging can be characterized in all living organisms as the inevitable biological changes that occur with advancing age. The aging process is time-dependent and leads to functional declines and increased incidences of disease. The underlying pathphysiologic processes of aging...

Growth hormone and aging.

Journal of the American Aging Association

Bartke A, Brown-Borg H, Kinney B, Mattison J, Wright C, Hauck S, Coschigano K, Kopchick J.
PMID: 23604867
J Am Aging Assoc. 2000 Oct;23(4):219-25. doi: 10.1007/s11357-000-0021-x.

The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with...

Effects of aging and resistance exercise on determinants of muscle strength.

Journal of the American Aging Association

Lambert CP, Evans WJ.
PMID: 23604898
J Am Aging Assoc. 2002 Apr;25(2):73-8. doi: 10.1007/s11357-002-0005-0.

Although the loss of muscle strength with aging is multifactorial, the primary factor is the loss of muscle mass. A preferential loss of Type II (fast-twitch) muscle fibers which produce more force than Type I fibers is also observed....

Stem cells from birth to death: The history and the future.

Journal of the American Aging Association

de Haan G, Van Zant G.
PMID: 23604899
J Am Aging Assoc. 2002 Apr;25(2):79-86. doi: 10.1007/s11357-002-0006-z.

The concept that adult stem cells, despite their impressive proliferative potential, are immortal has been challenged by experimental studies of hematopoietic stem cells. In this review, we discuss the properties that characterize a stem cell, the growing list of...

Patterns of metabolic activity during aging of the wild type and longevity mutants of Caenorhabditis elegans.

Journal of the American Aging Association

Braeckman BP, Houthoofd K, Vanfleteren JR.
PMID: 23604840
J Am Aging Assoc. 2000 Apr;23(2):55-73. doi: 10.1007/s11357-000-0007-8.

At least three mechanisms determine life span in Caenorhabditis elegans. An insulin-like signaling pathway regulates dauer diapause, reproduction and longevity. Reduction-or loss-of-function mutations in this pathway can extend longevity substantially, suggesting that the wild-type alleles shorten life span. The...

Showing 1 to 12 of 49 entries